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MRI identifies structural and functional defects deep in the lungs of patients with asthma. MRI is mainly used to visualize the airspaces of the large airways and parenchyma. He-3 MRI (Hyperpolarized helium) is used in asthma and highly sensitive in identifying ventilation defects in asymptomatic patients with normal lung function.He-3 MRI of ventilation visualizes obstructive patterns which are used to determine the asthma phenotypes. |
References
1: Kauczor HU, Chen XJ, van Beek EJ, Schreiber WG. Pulmonary ventilation imaged
by magnetic resonance: at the doorstep of clinical application. Eur Respir J.
2001 May;17(5):1008-23.
Pubmed
2: Beckmann N, Tigani B, Mazzoni L, Fozard JR. MRI of lung parenchyma in rats and
mice using a gradient-echo sequence. NMR Biomed. 2001 Aug;14(5):297-306. Pubmed
3: Tigani B, Schaeublin E, Sugar R, Jackson AD, Fozard JR, Beckmann N. Pulmonary
inflammation monitored noninvasively by MRI in freely breathing rats. Biochem
Biophys Res Commun. 2002 Mar 22;292(1):216-21.
Pubmed
4: Wagers S. Polarized helium: changing our view of asthma. J Allergy Clin
Immunol. 2003 Jun;111(6):1201-2.
Pubmed
5: Kokturk N, Demir N, Kervan F, Din Pubmed
6: de Lange EE, Altes TA, Patrie JT, Gaare JD, Knake JJ, Mugler JP 3rd,
Platts-Mills TA. Evaluation of asthma with hyperpolarized helium-3 MRI:
correlation with clinical severity and spirometry. Chest. 2006
Oct;130(4):1055-62.
Pubmed
7: Fain SB, Gonzalez-Fernandez G, Peterson ET, Evans MD, Sorkness RL, Jarjour
NN, Busse WW, Kuhlman JE. Evaluation of structure-function relationships in
asthma using multidetector CT and hyperpolarized He-3 MRI. Acad Radiol. 2008
Jun;15(6):753-62.
Pubmed
8: Tashkin DP, de Lange EE. Imaging of the distal airways. J Allergy Clin
Immunol. 2009 Dec;124(6 Suppl):S78-83.
Pubmed
9: Fain SB, Korosec FR, Holmes JH, O'Halloran R, Sorkness RL, Grist TM.
Functional lung imaging using hyperpolarized gas MRI. J Magn Reson Imaging. 2007
May;25(5):910-23.
Pubmed
10: Altes TA, Salerno M. Hyperpolarized gas MR imaging of the lung. J Thorac
Imaging. 2004 Oct;19(4):250-8.
Pubmed
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